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ALS destroys motor neurons, progressively paralyzing every voluntary muscle in the body. 80% of patients die within 5 years — typically from respiratory failure. The key driver is TDP-43 protein misfolding and aggregation inside motor neurons. Distributed simulation maps how TDP-43 aggregates form and spread between cells, identifying molecular intervention points that could halt progression. Supported by the ALS Research Institute and Harvard Medical School.
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