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Childhood acute lymphoblastic leukemia (ALL) is medicine's greatest pediatric oncology success story — and still kills thousands annually through treatment resistance. Your computer runs gene expression alignment tasks that build a resistance predictor: a model identifying which leukemia cells carry resistance signatures before treatment begins. This enables oncologists to select protocols that overcome resistance upfront, saving lives that current protocols miss. Supported by St. Jude Children's Research Hospital and WHO Oncology.